Department of Cellular Physiology

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before 1998 | 1999 - 2001 | 2002 - 2004 | 2005 - 2007| 2008 - 2010 | 2011 - 2013 | 2014 - 2016 | 2017 - 2019 | since 2020

since 2020

2017 - 2019

2014 - 2016

2011 - 2013

2008 - 2010

  • Voigtländer, T, Unterberger U, Guentchev M, Schwaller B, Celio MR, Meyer M, Budka H. The role of parvalbumin and calbindin in D28k in experimental scrapie. Neuropath Appl Neurobiol 34, 435-445 (2008).
  • Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats. Ziomber A, Machnik A, Dahlmann A, Dietsch P, Beck FX, Wagner H, Hilgers KF, Luft FC, Eckardt KU, Titze J. Am J Physiol Renal Physiol. 295: F1752-63 (2008).

2005 - 2007

  • Osmoadaptation of Mammalian cells - an orchestrated network of protective genes. Christoph K, Beck FX, Neuhofer W. Curr Genomics. 8: 209-18 (2007).
  • Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress. Küper C, Bartels H, Fraek ML, Beck FX, Neuhofer W. Am J Physiol Cell Physiol. 293: C1971-82 (2007).
  • Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions. Neuhofer W, Steinert D, Fraek ML, Beck FX. J Physiol. 583: 287-97 (2007).
  • Role of focal adhesion kinase (FAK) in renal ischaemia and reperfusion. Holzapfel K, Neuhofer W, Bartels H, Fraek ML, Beck FX. Pflugers Arch. 455: 273-82 (2007).
  • Walking with myosin V. Sellers JR, Veigel C. Curr Opin Cell Biol. 18 : 68-73 (2006).
  • Cell volume regulation in the renal papilla. Beck FX, Neuhofer W. Contrib Nephrol. 152:181-97 (2006).
  • Survival in hostile environments: strategies of renal medullary cells. Neuhofer W, Beck FX. Physiology (Bethesda). 21: 171-80 (2006).
  • Expression and regulation of alphaB-crystallin in the kidney in vivo and in vitro. Michl M, Ouyang N, Fraek ML, Beck FX, Neuhofer W. Pflugers Arch. 452: 387-95 (2006).
  • Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3. Rust MB, Faulhaber J, Budack MK, Pfeffer C, Maritzen T, Didié M, Beck FX, Boettger T, Schubert R, Ehmke H, Jentsch TJ, Hübner CA. Circ Res. 98: 549-56 (2006).
  • Production of ammonium by Helicobacter pylori mediates occludin processing and disruption of tight junctions in Caco-2 cells. Lytton SD, Fischer W, Nagel W, Haas R, Beck FX. Microbiology. 151: 3267-76 (2005).
  • Response of renal medullary cells to osmotic stress. Beck FX, Neuhofer W. Contrib Nephrol. 148: 21-34 (2005). Ammonium affects tight junctions and the cytoskeleton in MDCK cells. Vastag M, Neuhofer W, Nagel W, Beck FX. Pflugers Arch. 449: 384-91 (2005).
  • Differential expression of heat shock protein 27 and 70 in renal papillary collecting duct and interstitial cells - implications for urea resistance. Neuhofer W, Fraek ML, Ouyang N, Beck FX. J Physiol. 564: 715-22 (2005).
  • Cell survival in the hostile environment of the renal medulla. Neuhofer W, Beck FX. Annu Rev Physiol. 67: 531-55 (2005).
  • Effect of ammonium on the expression of osmosensitive genes in Madin-Darby canine kidney cells. Neuhofer W, Vastag M, Fraek ML, Beck FX. J Physiol. 563: 497-505 (2005).
  • Load-dependent kinetics of myosin-V can explain its high processivity. Veigel C, Schmitz S, Wang F, Sellers JR. Nature Cell Biol. 7:861-9 (2005).
  • Malaria parasite actin filaments are very short. Schmitz S, Grainger M, Howell S, Calder LJ, Gaeb M, Pinder JC, Holder AA, Veigel C. J Mol Biol. 349: 113-25 (2005).

2002 - 2004

  • Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. Neuhofer W, Holzapfel K, Fraek ML, Ouyang N, Lutz J, Beck FX. Kidney Int. 65: 431-41 (2004).
  • Myosin VI: cellular functions and motor properties. Roberts R, Lister I, Schmitz S, Walker M, Veigel C, Trinick J, Buss F, Kendrick-Jones J. Philos Trans R Soc Lond B Biol Sci. 359: 1931-44 (2004).
  • Myosin VI: a multifunctional motor. Lister I, Roberts R, Schmitz S, Walker M, Trinick J, Veigel C, Buss F, Kendrick-Jones J. Biochem Soc Trans. 32: 685-8 (2004).
  • A monomeric myosin VI with a large working stroke. Lister I, Schmitz S, Walker M, Trinick J, Buss F, Veigel C, Kendrick-Jones J. EMBO J. 23: 1729-38 (2004).
  • A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Batters C, Wallace MI, Coluccio LM, Molloy JE. Philos Trans R Soc Lond B Biol Sci. 359: 1895-905 (2004).
  • Myo1c is designed for the adaptation response in the inner ear. Batters C, Arthur CP, Lin A, Porter J, Geeves MA, Milligan RA, Molloy JE, Coluccio LM. EMBO J. 23: 1433-40 (2004).
  • Harrington AW, Leiner B, Blechschmitt C, Arevalo JC, Lee R, Mörl K, Meyer M, Hempstead BL, Yoon SO, Giehl KM.  Secreted Pro-NGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc. Natl. Acad. Sci. U.S.A. 101, 6224-6230 (2004).
  • Feil R, Hartmann J, Luo C, Wolfsgruber W, Schilling K, Feil S, Barski JJ, Meyer M, Konnerth A, De Zeeuw CI, Hofmann F. Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J Cell Biol. 163: 295-302 (2003).
  • Dethleffsen K, Heinrich G, Lauth M, Knapik E, Meyer M.  Insert-Containing Neurotrophins in Teleost Fish and Their Relationship to Nerve Growth Factor. Mol Cell Neurosci. 24, 380-394 (2003).
  • Editorial: Molecular motors. Molloy JE, Veigel C. IEE Proc Nanobiotechnol. 150: 93 (2003).
  • Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers. Veigel C, Molloy JE, Schmitz S, Kendrick-Jones J. Nature Cell Biol. 5: 980-6 (2003).
  •  Molecular evolutionary convergence of the flight muscle protein arthrin in Diptera and hemiptera. Schmitz S, Schankin CJ, Prinz H, Curwen RS, Ashton PD, Caves LS, Fink RH, Sparrow JC, Mayhew PJ, Veigel C. Mol Biol Evol. 20: 2019-33 (2003).
  • Biophysics. Myosin motors walk the walk. Molloy JE, Veigel C. Science. 300: 2045-6 (2003).
  • Neck length and processivity of myosin V. Sakamoto T, Wang F, Schmitz S, Xu Y, Xu Q, Molloy JE, Veigel C, Sellers JR. J Biol Chem. 278: 29201-7 (2003).
  • Nanometre resolution tracking of myosin-1b motility. Wallace MI, Batters C, Coluccio LM, Molloy JE. IEE Proc Nanobiotechnol. 150: 134-40 (2003).
  • Egger V., Svoboda K. & Mainen Z.F. Mechanisms of lateral inhibition in the olfactory bulb: Efficiency and modulation of spike-evoked calcium influx into granule cells. J. Neurosci. 23, 7551-7559 (2003).
  • Recovery of cell volume and electrolytes of A6 cells after re-establishing isotonicity following hypotonic stress. Grosse T, Heid I, Oztürk I, Borgmann S, Beck FX, Dörge A. Pflugers Arch. 447: 29-34 (2003).
  • Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- mice. Beck FX, Neuhofer W, Dörge A, Giebisch G, Wang T. Pflugers Arch. 446: 100-5 (2003).
  • Barski JJ, Hartmann J, Rose CR, Hoebeek F, Moerl K, Noll-Hussong M, De Zeeuw CI, Konnerth A, Meyer M. Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. J Neuroscience 23, 3469-3477 (2002).
  • Lauth M, Spreafico F, Dethleffsen K, Meyer M. Stable and efficient cassette exchange under nonselectable conditions by combined use of two site-specific recombinases. Nucleic Acid Res. 31, e115 (2002).
  • Dethleffsen K, Mörl K, Meyer M. Control of local NGF mRNA synthesis by preformed factors rapidly released from peripheral nerves. Mol Cell Neurosci 20, 503-514 (2002).
  • Schwaller B, Meyer M, Schiffmann SN.  “New” functions for “old” proteins: The role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice. Cerebellum 1, 241-258 (2002).
  • Barski JJ, Mörl K, Meyer M. Conditional inactivation of the calbindin D-28k gene by Cre/loxP-mediated recombination. Genesis 32, 165-168 (2002). 
  • Barski JJ, Lauth M, Meyer M. Genetic targeting of cerebellar Purkinje cells: History, current status and novel strategies. Cerebellum 1, 111-118 (2002).

1999 - 2001

  • von Schack D, Casademunt E, Schweigreiter R, Meyer M, Bibel M, Dechant G. Complete ablation of the neurotrophin receptor p75NTR causes defects in both the vascular and nervous system. Nature Neuroscience 4, 977-978 (2001).
  • Giehl KM, Röhrig S, Bonatz H, Gutjahr M, Leiner B, Bartke I, Yan Q, Reichardt LF, Backus C, Welcher AA, Dethleffsen K, Mestres P, Meyer M. Endogenous BDNF and NT-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. J Neuroscience 21, 3492-3502 (2001).
  • Tucker KL, Meyer M, Barde YA. Neurotrophins are required for nerve growth during development. Nature Neuroscience 4, 29-37 (2001).
  • Regulation of TonEBP transcriptional activator in MDCK cells following changes in ambient tonicity. Neuhofer W, Woo SK, Na KY, Grunbein R, Park WK, Nahm O, Beck FX, Kwon HM. Am J Physiol Cell Physiol. 283: C1604-11 (2002).
  • Relationship between intracellular ionic strength and expression of tonicity-responsive genes in rat papillary collecting duct cells. Neuhofer W, Bartels H, Fraek ML, Beck FX. J Physiol. 543: 147-53 (2002).
  • Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ. Nature. 416: 874-8 (2002).
  • Molecular motors: force and movement generated by single myosin II molecules. Rüegg C, Veigel C, Molloy JE, Schmitz S, Sparrow JC, Fink RH. News Physiol Sci. 17: 213-8 (2002).
  • The gated gait of the processive molecular motor, myosin V. Veigel C, Wang F, Bartoo ML, Sellers JR, Molloy JE. Nature Cell Biol. 4: 59-65 (2002).Analysis of single-molecule mechanical recordings: application to acto-myosin interactions. Knight AE, Veigel C, Chambers C, Molloy JE. Prog Biophys Mol Biol. 77: 45-72 (2001).
  • Regulated overexpression of heat shock protein 72 protects Madin-Darby canine kidney cells from the detrimental effects of high urea concentrations. Neuhofer W, Lugmayr K, Fraek ML, Beck FX. J Am Soc Nephrol. 12: 2565-71 (2001).
  • Spreafico F, Barski JJ, Farina C, Meyer M. Mouse DREAM/calsenilin/KChip3: gene structure, coding potential and expression. Mol. Cell. Neurosci., 17, 1-16 (2001).
  • Cheron G, Schurmans S, Lohof A, d´Alcantara P, Meyer M, Draye JP, Parmentier M, Schiffmann SN. Electrophysiological behavior of Purkinje cells and motor coordination in calretinin knock-out mice. Progress in Brain Research 124, 299-308 (2000).
  • Barski JJ, Dethleffsen K, Meyer M. Cre Recombinase Expression in Cerebellar Purkinje Cells. Genesis 28, 93-98 (2000).
  • Lauth M, Moerl K, Barski JJ, Meyer M. Characterization of Cre-mediated cassette exchange after plasmid microinjection in fertilized mouse oocytes. Genesis 27, 153-158 (2000).
  • Bonatz H, Röhrig S, Mestres P, Meyer M, Giehl K. An axotomy model for the induction of cell death of rat and mice corticospinal neurons in vivo. J. Neurosci. Meth. 100, 105-115 (2000).
  • Airaksinen L, Virkkala J, Aarnisalo A, Meyer M, Ylikoski J, Airaksinen MS. Lack of Calbindin-D28k does not affect hearing level or survival of Hair Cells in acoustic trauma. ORL 62, 9-12 (2000).
  • Vecellio M, Schwaller B, Meyer M, Hunziker . and Celio M. Alteration in Purkinje-cell spines of calbindin D-28k and parvalbumin knock-out animals. Eur J Neurosci. 12, 945-954 (2000).
  • Almeida, OFX, Conde GL, Crochemore C, Demeneix BA, Fischer D, Hassan AHS, Meyer M, Holsboer F and Michaelidis, TM. Subtle shifts in the ratio between pro- and anti-apoptotic molecules following activation of corticosteroid receptors decide neuronal fate. FASEB J., 14, 779-790 (2000).
  • Heat shock proteins and the cellular response to osmotic stress. Beck FX, Grünbein R, Lugmayr K, Neuhofer W. Cell Physiol Biochem. 10: 303-6 (2000).
  • Molecular chaperones in the kidney: distribution, putative roles, and regulation. Beck FX, Neuhofer W, Müller E. Am J Physiol Renal Physiol. 279: F203-15 (2000).
  • Inner-medullary organic osmolytes and inorganic electrolytes in K depletion. Beck FX, Müller E, Fraek ML, Dörge A, Thurau K. Pflugers Arch. 439: 471-6 (2000).
  • An unexpectedly large working stroke from chymotryptic fragments of myosin II. Molloy JE, Kendrick-Jones J, Veigel C, Tregear RT. FEBS Lett. 480: 293-7 (2000).
  • Motion determination in actin filament fluorescence images with a spatio-temporal orientation analysis method. Uttenweiler D, Veigel C, Steubing R, Götz C, Mann S, Haussecker H, Jähne B, Fink RH. Biophys J. 78: 2709-15 (2000).
  • Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function. Schmitz S, Clayton J, Nongthomba U, Prinz H, Veigel C, Geeves M, Sparrow J. J Mol Biol. 295: 1201-10 (2000).
  • Transepithelial chloride conductance in amphibian skin: regulatory mechanisms and localization. Nagel W, Davis JM, Katz U. Pflügers Arch-Eur J Physiol 440:797-808 (2000).
  • Blood pressure and indices of glomerular filtration in hypertensive and normotensive Prague rats. Hellmann H, Davis JM, Thurau K. Kidney Blood Press Res 23:385-392 (2000).
  • Actin residue glu(93) is identified as an amino acid affecting myosin binding. Razzaq A, Schmitz S, Veigel C, Molloy JE, Geeves MA, Sparrow JC. J Biol Chem. 274: 28321-8 (1999).
  • The motor protein myosin-I produces its working stroke in two steps. Veigel C, Coluccio LM, Jontes JD, Sparrow JC, Milligan RA, Molloy JE. Nature. 398: 530-3 (1999).
  • Influence of NaCl, urea, potassium and pH on HSP72 expression in MDCK cells. Neuhofer W, Müller E, Grünbein R, Thurau K, Beck FX. Pflugers Arch. 439: 195-200 (1999).
  • Possible involvement of heat shock protein 25 in the angiotensin II-induced glomerular mesangial cell contraction via p38 MAP kinase. Müller E, Burger-Kentischer A, Neuhofer W, Fraek ML, März J, Thurau K, Beck FX. J Cell Physiol. 181: 462-9 (1999).
  • Hypertonicity-induced accumulation of organic osmolytes in papillary interstitial cells. Burger-Kentischer A, Müller E, März J, Fraek ML, Thurau K, Beck FX. Kidney Int. 55: 1417-25 (1999).
  • Inhibition of NaCl-induced heat shock protein 72 expression renders MDCK cells susceptible to high urea concentrations. Neuhofer W, Müller E, Burger-Kentischer A, Fraek ML, Thurau K, Beck FX. Pflugers Arch. 437: 611-6 (1999).
  • Sooy K, Schermerhorn T, Noda M, Surana M, Rhoten WB, Meyer M, Fleischer N, Sharp GWG., Christakos S. Calbindin-D28k controls Ca and insulin release: evidence obtained from calbindin-D28k knock-out mice and β cell lines. J. Biol. Chem., 274, 34343-9 (1999).
  • Schiffmann SN, Cheron G, Lohof A, d'Alcantara P, Meyer M, Parmentier M, Schurmans S. Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin. Proc. Natl. Acad. Sci. USA, 96, 5257-5262 (1999).
  • Cellerino A., Michaelidis T., Barski J.-J., Bähr M., Thoenen H., Meyer M. Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2 -/- mice. NeuroReport 10, 1-5 (1999).
  • Gillardon F., Moll I., Meyer M., Michaelidis T.M.  Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2 deficient mice. Cell Death & Differentiation 6, 55-60 (1999).
  • Smyth N, Vatansever H.S., Murray P., Meyer M., Frie C., Paulsson M., Edgar D. Absence of basement membranes after targeting the Lamc1 gene results in embryonic lethality due to failure of endoderm differentiation. J. Cell Biol. 144, 151-160 (1999).

before 1999

  • The stiffness of rabbit skeletal actomyosin cross-bridges determined with an optical tweezers transducer. Veigel C, Bartoo ML, White DC, Sparrow JC, Molloy JE. Biophys J. 75: 1424-38 (1998).
  • Cellular response to osmotic stress in the renal medulla. Beck FX, Burger-Kentischer A, Müller E. Pflugers Arch. 436: 814-27 (1998).
  • Cellular osmoregulation in kidney medulla. Beck FX, Guder WG, Schmolke M. Contrib Nephrol. 123:169-84 (1998).
  • Effect of ischemia on localization of heat shock protein 25 in kidney. Schober A, Burger-Kentischer A, Müller E, Beck FX. Kidney Int Suppl. 67: S174-6 (1998).
  • Hypertonicity affects heat shock protein 27 and F-actin localization in Madin-Darby canine kidney cells. Neuhofer W, Müller E, Burger-Kentischer A, Beck FX. Kidney Int Suppl. 67: S165-7 (1998).
  • Influence of osmotic stress on heat shock proteins 25 and 72 in mouse mesangial cells. Müller E, Burger-Kentischer A, Neuhofer W, Schober A, Beck FX. Kidney Int Suppl. 67: S162-4 (1998).
  • Cationic amino acid transporter mRNA expression in rat kidney and liver. Burger-Kentischer A, Müller E, Klein HG, Schober A, Neuhofer W, Beck FX. Kidney Int Suppl. 67: S136-8 (1998).
  • Expression of Na+/Cl-/betaine and Na+/myo-inositol transporters, aldose reductase and sorbitol dehydrogenase in macula densa cells of the kidney. Burger-Kentischer A, Müller E, Neuhofer W, März J, Thurau K, Beck FX. Pflugers Arch. 436: 807-9 (1998).
  • Quantitative morphology of renal cortical structures during compensatory hypertrophy. Pfaller W, Seppi T, Ohno A, Giebisch G, Beck FX. Exp Nephrol. 6: 308-19 (1998).
  • Cellular site of active K absorption in the guinea-pig distal colonic epithelium. Dörge A, Beck FX, Rechkemmer G. Pflugers Arch. 436: 280-8 (1998).
  • Bender R, Heimrich B, Meyer M, Frotscher M. Hippocampal mossy fiber sprouting is not impaired in brain-derived neurotrophic factor-deficient mice. Exp. Brain Res. 120, 399-402 (1998).
  • Klapstein GJ, Gray PA, Lieberman DN, Vietla S, Airaksinen MS, Thoenen H, Meyer M, Mody I. Calbindin-D28k (CB) fails to protect hippocampal neurons against ischemia in spite of its cytoplasmic calcium buffering properties: evidence from CB knockout mice. Neuroscience 85, 361-373 (1998).
  • Wässle H, Peichl L, Airaksinen MS, Meyer M. Calcium binding proteins in the retina of a calbindin-null mutant. Cell Tissue Res. 292, 211-218 (1998).
  • Glomerulus number and blood pressure in the Prague hypertensive rat. Hellmann H, Davis JM, Thurau K. Kidney Int 54 (Suppl 67) S211-S212 (1998).